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KMID : 0370220160600040187
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Yakhak Hoeji
2016 Volume.60 No. 4 p.187 ~ p.192
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The Combination of Chlorogenic Acid and Fluconazole Potentiates Antifungal Activity
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Han Yong-Moon
Rhew Zheong-Imm
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Abstract
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In this present study, we determined the ability of chlorogenic acid (CRA), a polyphenolic compound, to potentiate the antifungal activity of fluconazole (FCZ) against Candida albicans. The determination was investigated by a microdilution susceptibility method and in a murine model of cutaneous candidiasis due to C. albicans. Results showed that CRA had a dose-dependent antifungal activity; and when combined with FCZ, the antifungal activity was synergistic as determined by the microdilition susceptibility method. For example, a combination of CRA at 25 μg/ml plus FCZ at 0.1 μg/ml was approximately 3 times more effective than antifungal activity of FCZ alone at the same dose (P<0.01). This potentiation by CRA was almost equivalent to antifungal activity by FCZ alone at 0.5 μg/ml, displaying that the CRA potentiates FCZ’s antifungal activity by almost 5 times (P<0.01). Moreover, this combination demonstrated synergic activity against the cutaneous disease as well, resulting in approximately 3 times more greater antifungal activity than FCZ alone at 0.1 μg/mouse (P<0.01). This suggests that the combination therapy can reduce side effects caused by FCZ in clinical situations. In summary, CRA has a synergistic antifungal activity, which can be produced by combining CRA with FCZ. Therefore, our data strongly indicate that CRA can be a potential candidate as an antifungal agent for combination therapy
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KEYWORD
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chlorogenic acid, fluconazole, Candida albicans, antifungal, combination therapy, synergistic, cutaneous can didiasis
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